胺基胺/纳米纤维素混合型冷凝系统,具有pH响应释放特征,用于小肠道输送
Shuhan Feng1,2, Patrick Laurén1, Jacopo Zini1
1Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, Finland.
Gels (Basel, Switzerland)
|September 26, 2025
概括
由纤维素纳米纤维和pectin制成的新混合型冷凝提供了pH响应的药物输送. 这些基于多糖的系统显示了向口服药物输送到小肠的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 药物运输 药物运输 药物运输
背景情况:
- 基于多糖的材料,如纤维素纳米纤维和pectin正在探索凝载体.
- 将它们集成到结构修改的混合凝系统中需要进一步调查.
研究的目的:
- 开发和表征从阳离子纳米纤维纤维素 (aNFC) 和氨基化pectin (AP) 的pH响应混合cryogels.
- 评估它们在小肠药物输送方面的潜力.
主要方法:
- 混合型冷凝是使用各种aNFC/AP比率的冷干燥制造的.
- 一种模型药物的pH反应释放被评估在不同的pH值 (酸性和中性).
- 分析了与AP含量相关的机械性能和毛孔形态.
主要成果:
- aNFC/AP混合型冷凝表现出pH响应性行为,在pH3.0 (20-30分钟) 处药物释放时间延长,在pH>6.5 (1-2分钟) 处药物迅速释放.
- 增加的AP含量提高了机械强度和毛孔大小.
- 药物释放动力学受到冷凝形态和交联密度的影响.
结论:
- aNFC/AP混合型冷凝显示了在pH6.5-7.0.0之间的功能性pH响应窗口.
- 这些冷凝显示出作为口服药物递送系统的重大前景,用于准小肠.
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