在外科手术过程中局部应用的特兰胺酸与上腺素的有效性和安全性:系统性审查
Hedieh Keshavarz1, Weber Wei Chiang Lin1,2, Shawn Dodd1,2
1Faculty of Medicine and Dentistry; University of Alberta, Edmonton, AB T6G 1C9, Canada.
European burn journal
|September 26, 2025
概括
局部使用的酸 (TXA) 与上腺素可以安全地减少手术出血. 这次审查发现这种组合对各种程序有效,尽管对标准化的协议需要更多的研究.
科学领域:
- 手术创新 在外科创新.
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 局部使用的三胺酸 (TXA),通常与上腺素结合,用于缓解外科手术期间出血.
- 这一系统性审查批判性地评估了这种综合方法在各种手术环境中的安全性和有效性.
研究的目的:
- 系统地审查局部使用的松酸 (TXA) 与上腺素结合用于外科手术期间的出血控制的安全性和有效性.
- 评估一系列手术程序中的证据.
主要方法:
- 在8个数据库中进行了系统的文献搜索,截至2025年6月26日.
- 包括的研究比较了手术患者的局部或局部TXA与上腺素与单独的上腺素,遵守PRISMA指南.
- 排除标准包括动物研究,病例报告,非英语出版物和缺乏对比物的研究.
主要成果:
- 纳入了10项研究 (4项随机,6项非随机),涵盖了诸如烧伤手术,节律切除术和关节关节整形等手术.
- 局部TXA与上腺素证明减少了手术内流血,增强了手术现场可见性,减少了排水量和降低了输血率.
- 没有报告发生血栓栓塞事件或重大并发症的显著增加.
结论:
- 局部特兰胺酸 (TXA) 和上腺素的组合显示出对安全有效的外科手术期间出血管理的承诺.
- 剂量和结果措施的异质性需要进一步研究,以建立标准化方案并确认长期安全性.
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