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Maxwell Sandberg^1,2, David Thole¹, Jackson Nowatzke¹

¹Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA.

Current oncology (Toronto, Ont.)

|September 26, 2025

概括

焦点疗法如HIFU,冷和IRE提供了更少的侵入性前列腺癌 (PCa) 治疗. 这些方法显示了足够的癌症控制和最小的影响功能与可比的成本在这个案例系列.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
最少侵入性的手术

背景情况:

前列腺癌 (PCa) 管理传统上涉及整个腺体的治疗,如手术或辐射.
焦点疗法为局部PCa提供了一个不那么侵入性的替代方案.
关于不同焦点治疗的功能结果和成本效益的比较数据有限.

研究的目的:

为PCa.提供高强度聚焦超声波 (HIFU),冷和不可逆向电穿孔 (IRE) 的案例系列.
为了对这些焦点疗法进行成本分析.
对焦点PCa治疗结果的文献进行审查.

主要方法:

对45名患者进行局部PCa的焦点HIFU,冷移除或IRE的回顾性审查.
排除接受全腺治疗的患者.
收集功能性结果数据 (勃起功能障碍,尿路症状) 和成本数据.

主要成果:

在焦点治疗前和后的PSA水平中没有发现显著差异.
三名患者经历了需要活检的生化复发.
平均成本为3804.50美元,治疗方式之间没有显著的成本差异.
在中位数6个月的随访期间,没有发生转移性事件或死亡.
功能性结果基本保持不变.

结论:

焦点疗法 (HIFU,冷移除,IRE) 提供了局部PCa的足够的短期癌症控制.
这些治疗方法的成本可比,对功能结果的影响最小.
需要进行更长时间的随访进一步研究,以充分评估长期疗效和瘤控制.

关键词:

这就是HIFU.这是爱尔兰.结冷除法结冷除结冷除焦点焦点的焦点焦点的焦点.前列腺癌是前列腺癌.

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