代谢综合征集群和动脉硬:在随访研究中揭开心血管风险的早期预测因素
Agnė Jucevičienė1,2, Ligita Ryliškytė1, Jolita Badarienė1,2
1Clinic of Cardiovascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, M. K. Čiurlionio Str. 21, LT-03101 Vilnius, Lithuania.
Journal of cardiovascular development and disease
|September 26, 2025
概括
代谢综合征 (MetS) 组件集群和动脉硬性增加心血管事件的风险. 像WTBG和WTHBG这样的特定组合与更硬的动脉和更高的事件率有关.
科学领域:
- 心血管医学 心血管医学
- 代谢障碍 代谢障碍 代谢障碍
- 血管健康 血管健康
背景情况:
- 代谢综合征 (MetS) 是一组增加心脏病,中风和2型糖尿病风险的疾病.
- 动脉硬是心血管健康的关键指标,也是未来心血管事件的预测因素.
研究的目的:
- 评估不同代谢综合征 (MetS) 组件集群,动脉硬 (大动脉脉冲波速度[aPWV]和心血管指数[CAVI]) 和主要心血管事件之间的关联.
- 确定特定的MetS组件组合,预测心血管风险增加和动脉硬.
主要方法:
- 在5307名参与者 (40-64岁) 的前性队列研究中,有MetS,无心血管疾病.
- 监测主要心血管事件的平均随访时间为4.57年.
- 通过aPWV和CAVI测量的动脉硬度;对MetS集群,动脉硬度和心血管结果的统计分析.
主要成果:
- 3.34%的受试者经历了重大心血管事件.
- 具有四个 MetS 标准的个体比具有三个标准的个体有更高的事件风险.
- 高甘油和葡萄糖含量显著与风险增加有关.
- 特定的MetS集群 (WBG,WTHB) 和组合 (WBG,WTBG,WTHBG) 与心血管事件和较高的动脉硬性 (aPWV,CAVI) 有显著的关联.
- 集群WTBG和WTHBG与极度硬动脉 (aPWV>95百分位) 的几率增加了一倍多.
结论:
- 动脉硬度增加和更多的MetS成分与心血管事件的风险增加有关.
- 特定的MetS成分,特别是高水平的甘油三和葡萄糖,对这种风险有很大影响.
- 不良的MetS组件组合 (WTBG,WTHBG,WTB) 与极度硬动脉有很强的关联,这表明风险概况较高.
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