在失败的源泉循环中循环生物标志物:当前证据和未来方向
Cecilia Vecoli1,2, Lamia Ait-Alì1,2, Simona Storti2
1CNR Institute of Clinical Physiology, 54100 Massa, Italy.
Journal of cardiovascular development and disease
|September 26, 2025
概括
循环血液生物标志物显示出对监测Fontan循环患者的希望,但需要更多的研究. 大规模研究和人工智能集成对于开发可靠的非侵入性工具来早期检测并发症至关重要.
科学领域:
- 心脏病学 心脏病学
- 生物标志物研究 生物标志物研究
- 儿科和成人先天性心脏病
背景情况:
- 患有Fontan循环的患者面临着终身多器官并发症的风险.
- 增加成人生存率需要改进长期随访和早期连续检测策略.
- 迫切需要非侵入性监测工具来评估Fontan的生理学.
研究的目的:
- 对循环血液生物标志物的现有证据进行全面审查,以监测Fontan生理学.
- 在Fontan患者中分析与心脏功能障碍,全身炎症,内皮功能障碍,肝/功能障碍和骨代谢相关的生物标志物.
主要方法:
- 关于Fontan生理学的血清生物标志物的现有研究的叙述性综述.
- 对生物标志物的批判性分析反映了Fontan失败的关键病理机制.
- 探索人工智能 (AI),机器学习 (ML) 和"omics"研究的潜在应用.
主要成果:
- 几种生物标志物显示出反映Fontan患者系统性损伤和末端器官参与的潜力.
- 目前的数据对于标准化临床生物标志物建议是不够的,因为样本大小小小,种群异质.
- 有限的纵向数据阻碍了建立基于证据的指导方针.
结论:
- 大规模,前性,多中心研究对于确定Fontan患者临床上有用的生物标志物至关重要.
- 人工智能/ML方法可以整合异质数据集,以便更好地分析.
- 基于"Omics"的研究为发现新生物标志物和途径提供了希望,在Fontan患者管理中推进精准医学.
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