在COVID-19感染后,细肠细菌过度生长风险的逐步增加:基于全球人口的研究
Yilin Song1,2, Thai Hau Koo3, Benjamin D Liu4
1Department of Internal Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD 21201, USA.
Diseases (Basel, Switzerland)
|September 26, 2025
概括
在感染后12个月内,COVID-19显著增加了小肠细菌过度生长 (SIBO) 的风险. 这种风险在老年人中更高,并且与某些药物相关,需要对长期胃肠道健康进行临床警.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 胃肠道 (GI) 症状在COVID-19中很常见.
- 小肠细菌过度生长 (SIBO) 是COVID-19后的新出现的胃肠道并发症.
- 了解COVID-19后的SIBO患病率对于患者管理至关重要.
研究的目的:
- 为了确定COVID-19感染后SIBO的流行和发病率.
- 分析不同年龄人口的SIBO风险.
- 为了确定与COVID-19后SIBO相关的风险因素.
主要方法:
- 对TrinetX数据库的回顾性分析 (2022年1月 - 2024年5月).
- 包括被诊断患有COVID-19后SIBO的成年患者.
- 倾向性得分匹配和Kaplan-Meier生存分析,用于12个月内SIBO发病率.
主要成果:
- 与对照组相比,COVID-19患者的SIBO发病率显著增加.
- 随着感染后的时间,SIBO发病率逐渐增加,在12个月达到顶峰.
- 在老年人 (60-79岁) 和使用特定药物 (阿片类药物,PPI,抗腹药) 的患者中观察到SIBO风险增加.
结论:
- COVID-19是SIBO在第一年内发展的重要风险因素.
- 年龄和使用某些慢性药物与COVID-19后的SIBO风险较高有关.
- 推临床意识和有针对性的干预措施来管理COVID-19后的胃肠道问题.
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