患有慢性广泛疼痛的成年人肠道微生物群:系统性审查
Pui-Ying Leong1,2,3,4, Lin-Hong Shi5
1Division of Allergy, Immunology & Rheumatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Diseases (Basel, Switzerland)
|September 26, 2025
概括
肠道微生物群的改变与慢性广泛疼痛 (CWP) 相关,这是纤维肌痛症状. 目前的证据有限,需要对CWP患者的微生物向治疗进行更多研究.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 疼痛管理 疼痛管理
背景情况:
- 慢性广泛疼痛 (CWP),纤维肌痛 (FM) 的标志,越来越多地与肠道微生物群的变化有关.
- 精确的微生物变化和益生菌/益生菌在CWP/FM患者的有效性还不清楚.
研究的目的:
- 系统地审查关于CWP/FM肠道微生物群变化的证据.
- 评估针对CWP/FM的微生物向干预措施的治疗潜力.
主要方法:
- 在主要的科学数据库中进行全面的文献搜索.
- 基于肠道微生物群组成变化和涉及微生物群的治疗方法的研究分类.
- 从最初的432个研究组中,包括了11项符合特定标准的研究.
主要成果:
- 观察到CWP患者肠道微生物群的变化.
- 关于特定微生物变化的有限而异质的证据.
- 初步发现表明,dysbiosis在CWP病理生理学中可能发挥作用.
结论:
- 失生症可能在CWP发展中发挥作用.
- 需要进一步的高质量研究来证实基于微生物群的干预措施的治疗疗效.
- 需要更多的研究来澄清肠道微生物群在CWP/FM中的作用及其治疗潜力.
相关概念视频
Chronic Bowel Disorders: Introduction
747
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
747
Analgesia and Pain Management
1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
Irritable Bowel Syndrome I: Introduction
923
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
923
Assessment of the Gastrointestinal System I: Subjective Data
625
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
625


