用于血液透析应用的基于陶的空心纤维膜模块的制造和评估
Jae Yeon Hwang1, Sung Woo Han1, Seung Hee Huh1
1Department of Chemical and Biochemical Engineering, Dongguk University, Pildong-ro 1-gil, Jung-gu, Seoul 04620, Republic of Korea.
Membranes
|September 26, 2025
概括
这项研究引入了用于血液透析的新型 (Al2O3) 空心纤维陶膜. 优化的烧结温度提高了生物相容性,并实现了与商业聚合物膜相比的透析性能.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 化学工程是化学工程的重要组成部分.
背景情况:
- 血液透析依赖膜去除血液中的废物.
- 目前的聚合物膜在生物相容性和性能方面面临限制.
- 陶膜具有潜在的优势,但在血液透析应用中尚未得到充分探索.
研究的目的:
- 制造和评估用于血液透析的 (Al2O3) 空洞纤维陶膜.
- 研究烧结温度对膜特性和性能的影响.
- 评估开发的陶膜的血液兼容性和透析效率.
主要方法:
- (Al2O3) 空洞纤维膜是使用相位逆转方法制造的.
- 膜在三个不同的温度 (例如,1000°C,1100°C,1200°C) 烧结.
- 结构特征,蛋白质吸附和血液透析性能 (尿素去除,Kt/V) 在实验室规模模块中被系统评估.
主要成果:
- 与传统的聚合物膜相比,所有制造的Al2O3膜都表现出优越的蛋白质吸附阻力,这表明生物相容性得到了增强.
- 烧结温度的提高导致蛋白质吸附的减少,允许控制生物相容性.
- 在1200°C烧结膜的血液透析器在2小时内实现了90%的尿素去除,60分钟内达到Kt/V1.1的Kt/V,符合商业标准.
结论:
- (Al2O3) 空洞纤维陶膜是血液透析的一个有希望的替代品.
- 烧结温度是控制膜生物相容性和透析效率的关键参数.
- 优化的陶膜提供了与当前的聚合物基血液透析器相当或更高的性能.
相关概念视频
Hemodialysis I: Introduction
1.4K
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
1.4K
Hemodialysis II: Procedure and Complications
648
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
648
Dialysis
1.6K
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
1.6K
Dialysis
1.2K
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
1.2K
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
405
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
405
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
190
Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
190


