尿 1 H-NMR 代谢突出亮点 通过有机地中海饮食激活MIIA (微生物群-免疫-炎症轴)
Laura Di Renzo1, Simona Cesaroni2, Giulia Frank3,4
1Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
Metabolites
|September 26, 2025
概括
在地中海饮食中食用有机食品对肠道微生物和新陈代谢产生了积极的影响. 这种有机地中海饮食 (IMOD) 对免疫-炎症平衡的益处比传统食物更大.
科学领域:
- 代谢学 代谢学 代谢学
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 地中海饮食的健康益处是公认的,但有机与传统食物来源对系统代谢的影响尚不清楚.
- 了解饮食模式中的有机和常规食品之间的代谢差异对于公共健康至关重要.
研究的目的:
- 研究有机 (IMOD) 与传统 (IMNOD) 地中海饮食的代谢影响.
- 评估食品生产方法如何影响宿主新陈代谢和免疫-炎症轴.
主要方法:
- 一项对12名健康成年人的交叉研究,比较IMOD和IMNOD饮食.
- 用42种化合物的1H-NMR光谱分析尿中代谢物概况.
- 多变量和单变量统计分析以评估代谢反应.
主要成果:
- 这两种饮食都改善了一些尿路代谢物,但IMOD饮食引起了更显著的变化.
- IMOD增加了有益的代谢物,如TCA循环中间体,植物化合物 (trigonelline) 和宿主微生物群的共同代谢物.
- IMOD降低了发酵和与异生菌相关的代谢物,表明微生物群-免疫-炎症轴 (MIIA) 的有益调节.
结论:
- 在地中海饮食框架内的有机食品消费增强了宿主微生物群相互作用和免疫支持途径.
- 食品生产质量显著影响全身代谢健康,提供机理性见解.
- 研究结果支持有机食品的可获得性增加,以改善代谢健康.
相关概念视频
Urine Studies II: Urine Culture and Sensitivity Test
860
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
860
Urine Studies I: Urinalysis
1.2K
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
1.2K
Urinary Tract Infection II: Pathophysiology
570
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
570


