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聚糖的潜在抗氧化和神经保护作用从DigüeñeCyttaria espinosae中分离出来

Claudia Pérez¹, Fabián A Figueroa^1,2, Ignacio Tello¹

¹Laboratorio de Química de Productos Naturales, Departamento de Botánica, Facultad de Ciencias Naturales y Oceanográficas, Universidad de Concepción, Concepción 4030000, Chile.

Journal of fungi (Basel, Switzerland)

|September 26, 2025

概括

来自智利Cyttaria espinosae (CePs) 的多糖体对抗阿尔茨海默病相关毒性的抗氧化和神经保护作用. 这些化合物是无毒的,可以为大脑健康提供功能性食物的好处.

科学领域:

* 生物化学和药理学
*神经科学和自然产品化学

背景情况:

*阿尔茨海默病 (AD) 是一个日益严重的全球健康问题,β-粉样的积累与其发病有关.
*氧化应激和抗氧化能力降低与阿尔茨海默氏症的神经退行有关.
* 衍生的多糖因其潜在的神经保护和抗氧化功效而得到认可.

研究的目的:

* 调查来自*Cyttaria espinosae* Lloyd (CePs) 聚糖的抗氧化和神经保护潜力.
* 在细胞和胚胎模型中评估CeP对粉样β (Aβ) 诱导毒性的安全性和有效性.

主要方法:

*使用富里埃变换红外光谱 (FT-IR) 和气色谱-质谱 (GC-MS) 进行CeP的表征.
*通过DPPH和ABTS测定来评估抗氧化活性.
*对斑马鱼胚胎的细胞毒性和暴露于Aβ的PC-12细胞的神经保护的评估.

主要成果:

* CePs表现出显著的抗氧化能力,最大抑制率为32.14% (DPPH) 和19.10% (ABTS) 在10 mg mL-1下.
* CePs在斑马鱼胚胎中没有表现出毒性,并且在暴露于Aβ时保留了PC-12细胞活力.
*观察到CeP对Aβ毒性的显著抗氧化和神经保护作用.

结论:

* *Cyttaria espinosae* 多糖 (CePs) 具有重要的抗氧化和神经保护性质.
* CePs表现出良好的安全性,对斑马鱼胚胎无毒.
*这些发现突显了CeP作为功能成分的潜力,可以减轻氧化应激,并在阿尔茨海默病的背景下支持大脑健康.

关键词:

在Cyttaria espinosae中使用.菌类的多糖类是真菌的多糖类.神经保护神经保护这是一种β-粉样,β-粉样.

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