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罕见酵母分离物的抗真菌敏感性

Deniz Turan¹, Zafer Habip², Hakan Odabaşı³

¹Istanbul Provincial Health Directorate ISLAB-2 Central Laboratory, Prof. Dr. Süleyman Yalçın City Hospital, Kadıköy, 34722 Istanbul, Türkiye.

Journal of fungi (Basel, Switzerland)

|September 26, 2025

概括

罕见酵母菌感染的增加需要精确的鉴定和抗真菌敏感性测试. 这项研究确定了196种罕见的酵母,揭示了常见的物种,并突出了耐药性模式,以指导临床治疗.

科学领域:

医学真菌学医学真菌学
临床微生物学临床微生物学
传染性疾病传染性疾病

背景情况:

从临床样本中越来越多地分离稀有酵母,这给诊断带来了挑战.
准确的鉴定和抗真菌敏感性对于有效的患者管理至关重要.

研究的目的:

从临床标本中识别罕见的酵母,并确定它们的抗真菌敏感性概况.
提供指导罕见酵母菌感染治疗的数据.

主要方法:

用于酵母鉴定的矩阵辅助激光脱吸/电离飞行质谱时间 (MALDI-TOF MS).
欧洲抗菌感应性测试委员会 (EUCAST) 微稀释方法用于抗真菌感应性测试.
测试针对安福特瑞辛B,可纳,伏利可纳,波萨可纳,伊特拉可纳,伊萨武可纳和安尼杜拉.

主要成果:

发现了196种罕见的酵母分离物,其中*Candida lusitaniae*,*Magnusiomyces capitatus*,*Candida fabianii*和*Trichosporon asahii*是最常见的.
观测到的高最小抑制度 (MIC) 值是针对 * Magnusiomyces * spp., * Trichosporon * spp. 和 * Rhodotorula mucilaginosa * 的 echinocandins.
在 *Magnusiomyces* spp., *T. asahii*, *R. mucilaginosa* 和各种 *Candida* 种类中发现了高可纳MIC值.

结论:

准确识别罕见酵母对于临床微生物学实验室至关重要.
抗真菌敏感性测试对于指导治疗新出现的罕见酵母病原体至关重要.
在家族遗传相关的酵母物种中也发现了类似的抗真菌易感性模式.

关键词:

抗真菌易感性测试抗真菌易感性测试临床断点临床断点标识标识标识标识标识稀有酵母是一种稀有酵母.

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