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阶段分离调节的真菌生长,性发育,适应和合成生物学应用
Xinxin Tong1, Daixi Zhang1, Zhenhong Zhu2
1The Ministry of Education Key Laboratory of Standardization of Chinese Medicine, Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China, Resources Breeding Base of Co-Founded, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Journal of fungi (Basel, Switzerland)
|September 26, 2025
概括
环境线索触发真菌液体液相分离 (LLPS),形成无膜有机体 (MLOs). 本综述探讨了真菌生物学中的LLPS及其对生物技术的工程潜力.
科学领域:
- 生物物理学的生物物理.
- 分子生物学分子生物学
- 菌类学 菌类学是指菌类学.
背景情况:
- 液-液相分离 (LLPS) 驱动着从蛋白质和核酸中形成无膜有机体 (MLOs).
- 环境刺激在真菌蛋白中动态调节LLPS,影响生长,繁殖和适应.
研究的目的:
- 审查由LLPS形成的环境暗示触发的真菌凝结物的进展.
- 突出这些凝结物在真菌物理生物学和细胞过程中的作用.
- 讨论工程合成冷凝剂,以提高微生物细胞工厂的效率.
主要方法:
- 在真菌中对LLPS进行当前研究的文献综述.
- 分析LLPS在真菌转录,RNA修饰,翻译,PTM,运输和应激反应中的作用.
- 探索工程合成生物分子凝聚物的策略.
主要成果:
- 在由环境因素调节的真菌适应和发病过程中,LLPS至关重要.
- 凝固剂调节关键的细胞过程,包括基因表达和压力管理.
- 工程LLPS为改善微生物工厂中的生物合成和代谢效率提供了潜力.
结论:
- 环境暗示诱导的LLPS是真菌生物学和细胞功能的关键调节者.
- 通过合成冷凝剂工程利用LLPS为生物技术应用和真菌中的代谢工程提供了一个有前途的途径.
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