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来自Arthrospira platensis的物理白蛋白提取物增强了太平洋 (Magallana gigas) 的免疫功能

Aleksandra Andreyeva¹, Tatyana Kukhareva¹, Anastasiya Tkachuk¹

¹Laboratory of Ecological Immunology of Aquatic Organisms, A.O. Kovalevsky Institute of Biology of the Southern Seas of RAS, 119991 Moscow, Russia.

|September 26, 2025

概括

使用蓝藻细菌提取物的功能性料可以提高的免疫力. 这项研究表明,Arthrospira platensis phycobiliproteins增强了太平洋的免疫细胞和基因表达,为化场的疾病预防提供了潜力.

科学领域:

水产养殖和海洋生物学
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

功能性料对健康至关重要,特别是在化场.
疾病预防是养殖的一个关键挑战.
菌提取物显示出作为天然免疫调节剂的前景.

研究的目的:

为了评估来自太平洋 (Magallana gigas) 的 Arthrospira platensis 的水性 phycobiliproteins 提取物 (CBPs) 的免疫调节作用.
评估CBP对血细胞功能和免疫基因表达的影响.
确定CBP作为功能性料添加剂的潜力,以增强的免疫力.

主要方法:

成年太平洋被用CBP提取物的不同度 (2,20,80微克/毫升) 治疗了24-96小时.
在体内分析血细胞功能,包括细胞化,溶酶体含量,线粒体膜潜力和反应性氧物种的产生.
在CBP提取物暴露后,对的中hsp70和hsp90基因表达的监测.

主要成果:

在血细胞中,CBP提取物增强了 fagocytosis, lysosomal 含量和线粒体膜潜力.
活性氧物种的产生被CBP提取物抑制.
较高的CBP度 (80μg/mL) 显示出对细胞形成的快速影响,而较低的度 (2μg/mL) 显示出后期的效应.
Hsp70基因表达最初是下调的,但恢复了,而hsp90表达始终是上调的.

结论:

来自Arthrospira platensis的CBP的水性提取物有效地增强了太平洋的细胞免疫反应.
对于双虫化场而言,CBPs显示出作为快速起作用的免疫调节剂的潜力.
这项研究支持在功能性料中使用CBP等天然化合物,以改善水产养殖健康和抗病能力.

关键词:

抗氧化剂活性抗氧化剂活性水产养殖的水产养殖免疫调节免疫调节免疫调节生物质蛋白质 (phycobiliproteins) 是一种生物质蛋白质.这是太平洋.

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