集成增材制造和传统制造用于多规模骨组织工程支架
Yixuan Zhu1, Haotian Gao1, Qingchen Qiao1
1School of Stomatology, Capital Medical University, Beijing 100070, China.
Journal of functional biomaterials
|September 26, 2025
概括
增材制造 (AM) 在骨组织工程 (BTE) 支架方面表现有前途. 将AM与传统方法相结合,可以创建复杂的多层次结构,以增强骨再生和临床转化.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 再生医学是一种再生医学.
背景情况:
- 增材制造 (AM) 为骨组织工程 (BTE) 提供生物仿真支架的精确制造.
- 只有AM在复制本地骨的多层次层次结构方面面临限制.
- 传统的制造方法可以补充AM来克服这些局限性.
研究的目的:
- 从多尺度设计的角度系统地审查最近在构建异质支架方面的进展.
- 强调AM技术与骨架制造传统方法的整合.
- 探索现场制造策略和多尺度集成支架的途径.
主要方法:
- 审查主要的AM技术 (基于挤出,基于光) 结合冷干燥,气泡和电.
- 专注于新兴的现场制造策略,如现场泡和矿化.
- 对构建多尺度集成支架的方法进行分析.
主要成果:
- 增强制造和传统方法的整合使得可以制造具有可控制的宏观,中等和微观架构的支架.
- 在现场的策略允许空间解决和功能分级的脚手架设计.
- 确定了创建具有增强生物性能的多规模集成支架的途径.
结论:
- 将AM与传统技术相结合,对于复制骨复杂的层次结构至关重要.
- 新兴的现场方法为脚手架架构和功能提供了先进的控制.
- 这一审查为开发下一代BTE支架提供了一个框架,该支架具有更好的临床翻译潜力.
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