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便秘和发生的心血管疾病:全国性的现实世界队列研究

Keiichiro Iwasaki¹, Kentaro Ejiri¹, Hidehiro Kaneko²

¹Department of Cardiovascular Medicine, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

|September 26, 2025

概括

便秘与心血管疾病 (CVD) 风险增加有关,包括心力衰竭和中风. 这种常见的情况可能会改善CVD预测超出已确定的因素.

科学领域:

流行病学流行病学
心脏病学心脏病学
胃肠病学胃肠病学

背景情况:

便秘和心血管疾病 (CVD) 之间的联系是建议的,但在一般人群中研究不足.
很少有研究评估便秘对未来心血管疾病事件的预测价值.

研究的目的:

量化便秘与患心血管疾病的风险之间的关联.
用日本全国数据库评估便秘在心血管疾病归因中的作用.

主要方法:

从DeSC数据库 (2014年4月至2022年11月) 获得的1,516,763个人没有先前心血管疾病的大规模研究.
根据ICD-10代码定义的便秘;使用多变量Cox模型评估的发生性心血管疾病 (MI,胸痛,中风,高压,AF).

主要成果:

便秘 (12.3%的队列) 与复合心血管疾病和单个事件显著相关,特别是心力衰竭 (HF).
便秘显示为复合心血管疾病,中风,高血压和心房动 (AF) 的第二高的人口归因分数.
将便秘添加到危险因素中,轻微改善了心血管疾病预测 (复合心血管疾病的净重新分类改善:0.122).

结论:

便秘与发生的心血管疾病有关,包括以前没有心血管疾病的个人心肌梗塞,心痛,中风,高血压和AF.
便秘对预测未来心血管疾病具有前途,强调其作为潜在心血管风险因素的重要性.
这表明便秘不仅仅是一个生活质量问题,并且在心血管风险评估中需要注意.

关键词:

心血管疾病心血管疾病便秘便秘便秘便秘心脏衰竭是因为心脏衰竭.心肌梗塞的心脏病发作一次性中风中风中风中风中风

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