结核病患者肺功能受损和生活质量结果:一个横截面研究
Varshini Jagadeesh1, Prashanth Chikkahonnaiah1, Muskan Dubey2
1Department of Pulmonary Medicine, Mysore Medical College and Research Institute, Mysuru 570001, Karnataka, India.
Tropical medicine and infectious disease
|September 26, 2025
概括
结核病显著损害肺功能和运动耐受性,导致生活质量下降. 耐药结核病进一步加剧了这些问题,强调需要治疗后查和控制策略.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 生活质量研究 研究 生命质量研究
背景情况:
- 结核病 (TB) 仍然是全球领先的传染病,而印度承担了相当大的负担.
- 结核病治疗后的后果,包括肺功能障碍和运动耐受性降低,影响患者的健康相关生活质量 (HRQoL).
研究的目的:
- 评估结核病对肺功能和运动耐受性的影响.
- 检查这些障碍如何影响与健康相关的生活质量 (HRQoL).
- 评估耐药结核病 (DR-TB) 对这些结果的影响.
主要方法:
- 一项涉及96名细菌学确诊的结核病患者和96名对照者的横截面研究.
- 进行了肺功能测试 (精神测量) 和六分钟步行测试 (6 MWT).
- 使用圣乔治呼吸道问卷 (SGRQ) 评估了与健康相关的生活质量 (HRQoL).
主要成果:
- 与对照组相比,结核病患者的FEV1,FVC和FEV1/FVC比率显著降低 (p < 0.001).
- 耐药结核病 (DR-TB) 与降低的螺旋指数和6MWT距离 (241米对抗药性结核病358米) 相关.
- 结核病患者在所有SGRQ领域 (症状,活性,影响; p <0.05) 报告了显著较差的HRQoL,得分与肺功能相反相关.
结论:
- 结核病导致持续的肺功能障碍和运动耐受性降低,即使在治疗后也显著影响HRQoL.
- 耐药结核病带来更大的功能负担,需要采取有针对性的控制措施.
- 常规的结核病后功能查对于全面的患者管理和实现结核病终结目标至关重要.
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