减少家庭结核病传播:试点集群随机控制试验
Cinthya Ruiz-Tagle1, Romina Seguel1, Luis Villarroel2
1Departamento de Enfermedades Infecciosas del Adulto, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
概括
一个捆绑的干预措施,以减少肺结核患者的呼吸道暴露,并没有显著降低家庭接触者的新感染. 该研究发现,尽管努力实施隔离和限制措施,但对传染控制的益处有限.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 结核病治疗开始后的传染性持续时间还不清楚.
- 在家庭接触者 (HHCs) 中出现的新结核病感染是一个重大的公共卫生问题.
研究的目的:
- 评估捆绑干预措施的可行性,以减少呼吸道暴露.
- 确定这种干预措施是否能减少HHCs中的新结核病感染.
主要方法:
- 在智利圣地亚哥进行了一项试点集群随机对照试验.
- 干预包括教育,口罩使用,通风和两周的患者隔离.
- 在12周的随访期间,通过QuantiFERON®-TB Gold Plus (QFT) 试验转换测量HHCs的有效性.
主要成果:
- 在干预组中,QFT转换发生在12.8%的HHC中,在对照组中为10.8% (IRR为1.10,p=0.849).
- 呼吸捆干预的坚持是中度的,53-54%的人在两周内报告了良好的坚持.
- 这项研究招募了384名HHC和157名肺结核患者.
结论:
- 实施隔离和限制措施治疗后启动是具有挑战性的.
- 捆绑干预措施没有显著减少HHCs的结核病感染.
- 研究结果表明,这种干预措施对控制结核病传播的益处有限.
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