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Updated: Jan 16, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

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Published on: July 16, 2016

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I-BET151调节葡萄酶基因表达和β细胞功能,部分通过FOXO1表达的变化

Qing Wei Calvin Ho1, James A Miller1, Divya Gunaseelan1

  • 1Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.

Diabetologia
|September 26, 2025
PubMed
概括

抑制BET可能会损害胰腺β细胞功能. 这项研究发现,I-BET151降低了小鼠的葡萄糖调节和胰岛素分泌,影响了关键的β细胞基因. 建议在使用BET抑制剂治疗时谨慎使用.

关键词:
BET 蛋白抑制剂的使用贝塔细胞 贝塔细胞 贝塔细胞表观遗传调节器 表观遗传调节器这就是FOXO1的意义.GCK GCK 在线观看这就是HNF4a.在I-BET151中.这里是INS-1E.莫迪 (MODY) 的意思是说.胰腺小岛是一个小岛.

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