肺移植受体中SARS-CoV-2感染:日本单中心回顾性研究
Mikihiro Kohno1,2, Akihiro Ohsumi3,4, Jumpei Kimura1
1Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan.
Surgery today
|September 26, 2025
概括
肺移植患者的COVID-19发病率与普通人群相似,但疾病的严重程度仍然很高. 高龄,糖尿病和单边移植增加了这些脆弱患者的COVID-19严重程度.
科学领域:
- 移植手术 移植手术
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 肺移植 (LTx) 接受者面临严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染和死亡的风险较高.
- 关于2019年新冠病毒病 (COVID-19) 在日本LTx接受者的临床过程和结果的数据有限.
研究的目的:
- 为了确定日本LTx接受者的COVID-19的发病率,结果和临床特征.
- 分析与高风险人群中COVID-19严重程度相关的因素.
主要方法:
- 在京都大学医院进行了一项单中心回顾性研究.
- 包括LTx接受者从2020年3月至2023年6月进行了跟踪,涵盖了COVID-19大流行期间.
主要成果:
- 在230名LTx接受者中,64人 (27.8%) 感染了SARS-CoV-2;一名患者 (1.6%) 死于COVID-19.
- 随着变种的演变,疾病的严重程度下降,但在2022年之后仍然显著.
- 单边LTx,晚年和糖尿病与COVID-19严重程度的增加有关.
结论:
- 在LTx接受者的COVID-19发病率反映了日本一般人口,但严重程度仍然存在.
- 持续开发预防和早期治疗策略对于LTx接受者至关重要.
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