患有神经omyelitis optica光谱障碍的患者的ofatumumab治疗:一个回顾性多中心队列研究
Xiaoxia Yang1,2, Zhen Jia3,4,5, Xuegan Lian2
1Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Journal of neurology
|September 26, 2025
概括
在神经脊髓炎光学谱系障碍 (NMOSD) 患者中,ofatumumab治疗显著降低了复发率和残疾. 反CD20抗体还降低了AQP4-IgG标位,证明了NMOSD管理的可接受的安全性.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 临床治疗学 临床治疗学
背景情况:
- 奥法图马布是一种B细胞耗尽的抗CD20单克隆抗体.
- 有限的数据存在于ofatumumab在神经髓炎光学谱系障碍 (NMOSD) 的疗效和安全性.
研究的目的:
- 评估NMOSD患者皮下注射ofatumumab的疗效和安全性.
- 评估ofatumumab对复发率,残疾和AQP4-IgG标位的影响.
主要方法:
- 在112名用ofatumumab治疗的NMOSD患者进行了回顾性多中心队列研究.
- 主要结局:年化复发率 (ARR). 二次结果:残疾分数 (EDSS,ALS),AQP4-IgG标位和安全.
- 平均随访时间为1.7年.
主要成果:
- 中位数ARR从2.0降低到0 (p < 0.001) 的显著降低.
- 在EDSS分数显著改善 (p < 0.001).
- 76%的患者显示AQP4-IgG标位降低;一般可接受的安全性与可管理的不良事件,如注射反应和感染.
结论:
- 皮下注射ofatumumab有效降低了NMOSD中的复发风险和残疾进展.
- 奥法图马布治疗导致AQP4-IgG标位降低.
- 在NMOSD中,ofatumumab的安全性概况通常是可以接受的,因此需要进一步调查持续反应.
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