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基于前列腺癌免疫景观分层的代谢相关预后风险模型的开发

Yuanting Liu¹, Yixiao Shi¹, Yujie Cao¹

¹Operating Room, West China Hospital, Sichuan University/West China School of Nursing, Chengdu, China.

Discover oncology

|September 26, 2025

概括

前列腺癌 (PCa) 呈现出不同的代谢亚型,影响免疫透和预后. 一个基于新陈代谢的新型风险评分有效预测患者的生存率,并可能指导治疗策略.

科学领域:

在瘤学瘤学.
代谢途径代谢途径
免疫学免疫学免疫学

背景情况:

代谢重编程和免疫格局的变化是前列腺癌 (PCa) 进展和治疗耐药性的关键.
瘤新陈代谢,免疫细胞透和患者结果之间的关系尚未得到充分理解.

研究的目的:

研究前列腺癌中代谢异质性和免疫微环境之间的相互作用.
开发和验证基于PCa患者代谢特征的新型预后模型.

主要方法:

利用PCa患者的癌症基因组图谱 (TCGA) 的转录和临床数据.
应用ssGSEA来定义代谢亚型和CIBERSORT/xCell用于免疫透分析.
开发了一种代谢风险评分和一个整合临床因素用于预测存活率的诺姆图.

主要成果:

确定了两种代谢亚型 (代谢_H和代谢_L),具有不同的代谢概况,免疫透和临床结果.
代谢_H亚型显示脂质/氨基酸代谢升高,免疫抑制微环境,预后较差.
14基因代谢风险得分显著分层整体存活率 (p < 0.001) 并与PD-L1表达和免疫排除相关.

结论:

前列腺癌表现出显著的代谢和免疫异质性.
一个基于新陈代谢的新型预后模型提供了改进的风险分层和潜在的治疗点.
调节瘤代谢可以增强免疫反应,改善PCa的治疗结果.

关键词:

免疫系统的透.拉索·拉索 (Lasso) 是一个代谢过程中的代谢.在PD-L1中.预测模型是一个预测模型.前列腺癌是什么意思前列腺癌是什么意思在TCGA中,TCGA就是TCGA.这就是SSGSEAEA.

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