药剂师领导的干预计划的实施忠实性,以改善血液透析患者的高血清酸盐度:混合方法研究
F J van den Oever1,2, E C Vasbinder3, Y C Schrama3
1Department of Pharmacy, Franciscus Gasthuis and Vlietland, Kleiweg 500, 3045 PM, Rotterdam, The Netherlands. c.vandenoever@franciscus.nl.
International journal of clinical pharmacy
|September 26, 2025
概括
药剂师干预和酸盐结合药物的剂量优化 (PIDO-P) 显示了中度至高的实施忠实度,但没有显著降低血清酸盐度. 改善对具有较高酸盐水平的患者的选择可能会提高干预的有效性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 实施科学 实施科学
背景情况:
- 药剂师干预和酸盐结合药物的剂量优化 (PIDO-P) 旨在降低高血清酸盐度 (SPC) 在血液透析患者高药物负担.
- 虽然PIDO-P改善了对酸盐结合药物 (PBM) 的坚持,但它并没有有效地降低SPC.
研究的目的:
- 使用混合方法方法评估PIDO-P干预的实施忠实性 (IF).
- 确定影响PIDO-P干预成功实施的因素.
主要方法:
- 一个融合混合方法设计评估IF使用卡罗尔的框架在75个血液透析患者.
- 数据通过研究管理记录,患者/药剂师调查,半结构面试和电子医疗记录收集.
- 使用描述性统计数据分析了定量数据,并进行了定性数据的主题分析.
主要成果:
- 实施忠实度一般为中度至高,但在选过程和书面摘要交付方面 (65.3%) 有所例外.
- 便利化策略是有效的,药剂师发现干预是可行的,不是过于复杂的.
- 关键的IF主题包括患者知识,正确的PBM使用,治疗个性化以及药剂师与患者的关系.
结论:
- 由于PIDO-P干预对SPC缺乏影响,这并不能归因于实施忠实度低.
- 针对基线SPC较高的患者 (>2.0 mmol/L) 和完善患者选择标准可能会提高干预的有效性.
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