优化血脑屏障的透性:葡萄酒加工对Phellodendri Chinensis Cortex中的类化合物的影响
Shuo Zhang1, Jiahui Zhao2, Wenjing Ren1
1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning Province, Dalian, 116600, People's Republic of China.
Journal of natural medicines
|September 26, 2025
概括
葡萄酒加工增强了Phellodendri Chinensis皮层 (PC) 类的血脑屏障 (BBB) 透. 这种传统方法通过改变运输路径来改善大脑药物输送,验证古老的做法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 草药研究 草药研究
背景情况:
- 菲洛登德里金尼西斯皮层 (PC) 含有具有潜在治疗益处的类化合物.
- 传统中医经常采用像葡萄酒处理这样的加工方法来处理草药成分.
- 了解这些处理方法如何影响药物输送,特别是通过血脑屏障 (BBB),至关重要.
研究的目的:
- 研究葡萄酒加工对来自Phellodendri Chinensis Cortex (PC) 的关键类化合物的BBB透性的影响.
- 阐明葡萄酒加工增强PC类化合物的大脑分布的机制.
- 为传统的草药加工技术提供科学验证.
主要方法:
- 使用UPLC-QqQ-MS进行植物化学分析,以比较原始PC (RPC) 和葡萄酒加工PC (WPC).
- 在小鼠体内研究以评估大脑化物分布.
- 在体外BBB模型使用bEnd.3细胞和星体细胞来评估化物透性.
- 西方涂抹和配体捕捞试验用于分析紧结蛋白和传送器相互作用.
主要成果:
- 葡萄酒加工显著改变了PC的化物概况.
- 在体内,WPC治疗导致主要类化合物的大脑分布增强.
- 在实验室中,WPC类化合物显示了增加的BBB透性,与下调的紧结蛋白 (ZO-1,Occludin) 和P-糖蛋白相关,并增加了TfRc结合.
结论:
- 葡萄酒加工增强了Phellodendri Chinensis皮层 (PC) 类的血脑屏障 (BBB) 透.
- 这种增强是通过调节双细胞和跨细胞运输通路来实现的.
- 这些发现支持传统草药加工的科学基础,并为开发针对大脑的药物提供了洞察力.
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