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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Overview of Cell Death01:30

Overview of Cell Death

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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
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Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Phagocytosis of Apoptotic Cells01:17

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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Inflammation01:38

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相关实验视频

Updated: Jan 6, 2026

Visualization of Macrophage Lytic Cell Death During Mycobacterial Infection in Zebrafish Embryos via Intravital Microscopy
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细胞死亡和感染:对宿主和微生物的影响

Anna Davey1, Thibaut Sanchez1, Christopher D Lucas2

  • 1Centre for Inflammation Research, Institute for Regeneration & Repair, University of Edinburgh, Edinburgh, UK.

Advances in experimental medicine and biology
|September 26, 2025
PubMed
概括

编程细胞死亡对于组织健康至关重要. 本综述探讨了细胞死亡和清除如何影响微生物,特别是在肠道和肺部,开辟了新的研究途径.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.细菌 细菌是一种细菌.主体-微生物相互作用代谢过程中的代谢.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 微生物学 微生物学
  • 细胞生物学 细胞生物学

背景情况:

  • 编程细胞死亡是一个高度保守的,调节的过程,对组织平衡至关重要.
  • 肠道和肺部等面向外部的组织与微生物群落密切相互作用.
  • 虽然研究了对诱导细胞死亡的微生物的宿主反应,但对宿主细胞死亡的微生物反应不太了解.

研究的目的:

  • 为了审查宿主细胞-细胞通信事件下游的编程细胞死亡.
  • 要突出细胞死亡和清除如何影响共生和致病微生物.
  • 专注于宿主细胞死亡和肠道和肺部细菌群落之间的相互作用.

主要方法:

  • 文献综述侧重于编程细胞死亡,宿主-微生物相互作用和细胞-细胞通信.
  • 对亡,尸体清除和微生物代谢的现有研究进行分析.
  • 综合与肠道和肺部环境相关的发现.

主要成果:

  • 病原性微生物可以在感染期间操纵宿主细胞死亡途径.
  • 在亡过程中释放的微生物代谢物可以被某些细菌利用.
  • 宿主细胞死亡过程影响微生物群落的组成和行为.

结论:

  • 了解宿主细胞死亡和微生物之间的双向通信对于宿主-微生物平衡至关重要.
  • 需要进一步研究以阐明肠道和肺部等组织相互作用的具体机制.
  • 这种知识可以为针对宿主微生物失生症的治疗策略提供信息.