2015年至2021年间美国儿科牛皮系统治疗的流行率和趋势
Anna Ramond1, Theresa Rosario-Jansen2, Xinyu Yang3
1UCB, Slough, UK.
Dermatology and therapy
|September 26, 2025
概括
美国儿童牛皮的患病率仍然很低,但治疗已经发生了转变. 生物药物,特别是干白素抑制剂,越来越多地用于儿童和青少年中度至重症病例.
科学领域:
- 皮肤病学 皮肤病学
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 儿童牛皮的流行率和治疗模式自2015年以来没有更新.
- 生物药物可能已经显著改变了儿科牛皮的护理标准.
- 了解目前儿科牛皮的负担对于疾病意识至关重要.
研究的目的:
- 为提供美国儿科牛皮的最新流行情况.
- 分析目前儿科牛皮的治疗环境.
- 突出提高疾病意识和管理策略的必要性.
主要方法:
- 使用美国索赔数据的回顾性队列研究 (2015年7月至2021年10月).
- 从2016年至2020年,对儿科患者 (6-17岁) 的整体和中度至重度斑块性牛皮的患病率估计.
- 对中度至重症儿科牛皮的系统性/光疗治疗使用 (2017-2021) 的分析.
主要成果:
- 2020年,儿科牛皮的总体患病率为117.4/100,000;中度至重度为18.4/100,000.
- 在2017-2021年期间,治疗从非生物系统药物和光疗转向生物药物.
- 干白素抑制剂的使用显著增加,而TNF抑制剂的使用减少;乌斯特基努马布和伊克齐祖马布显示出显著的增长.
结论:
- 牛皮在美国儿童中仍然不常见,在2020年,15.9%的儿童患有中度至重度疾病.
- 对中度至重度儿科牛皮的治疗已经过渡.
- 这种转变有利于较新的干白素抑制剂,而不是较旧的非生物系统性和TNF抑制剂.
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