益生菌的消费减少了带膜骨损失和损伤在怀孕的老鼠与实验性牙周炎
Átila V V Nobre1, Pedro H F Silva1, Marina C G Del-Arco2
1Department of Oral and Maxillofacial Surgery and Periodontology, Ribeirao Preto Dental School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
Journal of periodontology
|September 26, 2025
概括
生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖HN019 (B.乳糖HN019) 益生菌补充剂改善了牙周炎 (PD) 孕妇大鼠的骨和脏健康. 这种益生菌菌株还增强了母婴和幼的体重和 litter 尺寸,减轻了PD的负面妊娠影响.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 牙周病学 牙周病学
背景情况:
- 生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖HN019 (B.乳糖HN019) 具有免疫调节特性,在牙周炎 (PD) 中具有证明的益处.
- 实验性牙周炎 (EP) 可以引起局部和全身损伤,可能影响怀孕的结果.
研究的目的:
- 调查B. lactis HN019在怀孕大鼠实验性牙周炎 (EP) 的局部和全身影响.
- 评估PD对怀孕的影响以及B. lactis HN019减轻这些影响的潜力.
主要方法:
- 48只怀孕的老鼠被分为控制,益生菌,牙周炎 (PD) 和牙周炎+益生菌 (PD-PROB) 组.
- 使用绑定模型和Porphyromonas gingivalis gavage诱导EP.
- 用微型CT,组织学和生物化学分析分析了下,脏和尿液.
主要成果:
- EP诱导了膜骨损失 (ABL) 和损伤;B. lactis HN019的使用改善了这些参数.
- 与PD组相比,PD-PROB组表现出更大的下骨体积,椎骨的厚度和骨孔隙性降低.
- 脏分析显示,PD-PROB组中的球体和曼囊直径减少.
结论:
- 系统的B. lactis HN019的管理减少了下骨和脏损伤在怀孕的老鼠与EP.
- 益生菌补充剂对母婴和幼的体重和 litter 尺寸产生了积极的影响.
- B. lactis HN019可以作为一种有效的辅助疗法,用于怀孕期间治疗牙周炎.
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