牙周炎和高酸盐摄入单独或组合对脏产生不利影响
Ae Ri Kim1,2,3, Min Seo Kim1,2, Jiwon Seo1
1Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Republic of Korea.
Journal of periodontology
|September 26, 2025
概括
高酸盐摄入量和牙周炎协同恶化损伤. 瘤亡因子-α (TNF-α) 抑制逆转了这些不良影响,这表明联合损伤的潜在治疗标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 牙周病学 牙周病学
- 免疫学 免疫学 免疫学
背景情况:
- 牙周炎和高酸盐 (HP) 摄入对脏健康构成风险,特别是在患有脏疾病的个体中.
- 本研究研究了这些因素在正常脏条件下对牙周和脏组织的影响.
研究的目的:
- 评估牙周炎和高酸盐 (HP) 摄入对牙周和脏组织的单独和联合影响.
- 评估TNF-α抑制在减轻相关损害方面的潜力.
主要方法:
- 鼠被分配到控制,HP饮食,牙周炎 (P) 或牙周炎与HP饮食 (P+HP) 组12周.
- 牙周炎是通过牙绑定诱导的;HP饮食含有0.9%的酸盐.
- 另外一个P+HP组每周接受TNF-α抑制剂infliximab (IFX).
主要成果:
- 摄入HP没有影响牙周组织;牙周炎没有随着摄入HP而恶化.
- 摄入HP增加了脏间歇性纤维化和Col1a1表达.
- 牙周炎增加了脏ED1表达;结合HP和牙周炎显著加剧了管状骨,间歇性纤维化和巨细胞透 (ED1).
- 在P+HP+IFX组中,IFX治疗减少了牙周炎症和脏变化.
结论:
- 高酸盐摄入量本身不会影响牙周健康.
- 结合性牙周炎和高酸盐摄入量对脏产生协同作用的不良影响,增加纤维化和巨细胞透.
- 抑制TNF-α显示出改善脏损伤的潜力,这种损伤是由牙周炎和高酸盐摄入量的联合伤害引起的.
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