与美国成年2型糖尿病患者使用葡萄糖类-1受体激动剂相关的模式和成本
Jun Wu1, Alexandra Perez1, Patrick W Sullivan1
1Department of Sociobehavioral and Administrative Pharmacy, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL.
Journal of managed care & specialty pharmacy
|September 26, 2025
概括
在2型糖尿病中使用类似葡萄糖-1受体激动剂 (GLP-1 RA) 显著增加了医疗保健成本. 尽管有保险覆盖,GLP-1RA导致糖尿病相关和全因支出增加.
科学领域:
- 内分泌学和新陈代谢学
- 卫生经济学 卫生经济学
- 药物经济学 药物经济学
背景情况:
- 类似葡萄糖-1受体激动剂 (GLP-1RA) 越来越多地用于糖尿病,减肥和预防心血管疾病.
- 高昂的成本和保险限制构成了GLP-1RA的接入障碍.
- 关于GLP-1 RA使用对2020年后美国糖尿病护理总医疗费用的影响的数据有限.
研究的目的:
- 调查美国2型糖尿病成年人GLP-1RA利用趋势.
- 分析GLP-1RA使用与整体医疗保健支出之间的关联.
主要方法:
- 使用的2021-2022医疗支出小组调查数据对美国成年人 (≥18岁) 患有2型糖尿病.
- 评估GLP-1RA使用情况,所有原因,以及与糖尿病相关的医疗保健费用 (医疗和处方).
- 采用了通用线性回归来确定GLP-1 RA使用对成本的影响,并对共变量进行调整.
主要成果:
- 在3587名符合条件的成年人中,18.8%的人报告使用GLP-1 RA,约占366万美国成年人.
- 对于GLP-1RA的平均年人均成本为6,947美元,占抗糖尿病药物成本的63.3%,占使用者的糖尿病总成本的55.7%.
- GLP-1 RA使用与糖尿病相关成本增加了219%,全因医疗保健总成本增加了55.3%.
结论:
- 自2020年以来,GLP-1 RA的利用在美国2型糖尿病成年人中显著增加.
- 尽管保险覆盖率很高 (>95%),但药物成本很高,是GLP-1RA相关的医疗保健支出增加的主要驱动因素.
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