贝塞特病中NETosis发现与疾病活性之间的关系:一项探索性研究
Erdem Bektas1, Rabia Deniz2, Zeliha Emrence3
1Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. erdmbektas@gmail.com.
Clinical and experimental rheumatology
|September 26, 2025
概括
中性粒细胞外细胞陷 (NETs) 和NETosis标记物显示出贝赫塞特病 (BD) 活动的不同水平. 经调整后的发现表明,在活跃的BD期间,中性粒细胞周转率会影响血清NETosis标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 病理生理学 病理生理学
背景情况:
- 贝切特病 (Behçet disease,简称BD) 是一种多系统性炎症性疾病,病因不明.
- 中性细胞外细胞陷 (NETs) 参与天生的免疫力,并与各种自身免疫性疾病有关.
- NETosis,NET形成的过程,是BD病原发生的潜在贡献者.
研究的目的:
- 调查NETosis发现与贝希特病的疾病活性之间的关联.
- 评估与健康对照组相比,活跃和不活跃的BD患者中NETosis的血清和唾液标志物.
主要方法:
- 对30名活跃的BD患者和10名健康对照者的横截面和纵向研究.
- 测量血清和唾液无细胞DNA (cf-DNA),中性粒细胞弹性酶 (NE),骨髓氧化酶 (MPO) 和素化基因素H3 (cit-H3) 作为NETosis标记物的测量.
- 调整 NETosis 标志物的外周血液中性粒细胞计数.
主要成果:
- 不调整的血清cf-DNA和NE在活跃的BD患者和对照人群中升高.
- 调整后的血清MPO和cit-H3水平在活性BD中较低.
- 唾液NETosis标志物在BD患者和对照人群之间没有显著差异.
- 纵向分析显示cf-DNA水平降低,疾病活性降低.
- cf-DNA与炎症标志物有正相关性,而调整后的MPO和cit-H3与炎症标志物有负相关性.
结论:
- 间接NETosis的发现是可变的,并且与BD中的系统和局部活动有关.
- 调整后的标志物水平表明,活性BD中中性粒细胞的增加会影响血清NETosis标志物.
- NETosis标志物可以作为疾病活动和中性粒细胞动态的指标,在贝希特病.
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