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来自巴西迪奥米切伪水的hirsutane 基烯酸,参见 cf. 帕拉布里斯在这里

Somporn Palasarn¹, Malipan Sappan¹, Kitlada Srichomthong¹

¹National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani, Thailand.

Natural product research

|September 26, 2025

概括

研究人员从真菌Pseudohydropus中发现了两种新的水素A和B基烯. 这些化合物与已知的hirsutanes一起,对NCI-H187癌细胞表现出较弱的细胞毒性.

科学领域:

自然产品化学自然产品化学
菌类学菌类学是指菌类学.
药用化学医学化学

背景情况:

菌是结构多样化的二次代谢产物的丰富来源.
塞斯基二烯是一种特类的物质,通常表现出显著的生物活性.
表观遗传调节剂尼古丁胺胺可以影响真菌的二次代谢.

研究的目的:

为了隔离和描述Pseudohydropus中的新型甲,参见. 一个叫做parafunebri的.
为了研究与癌症细胞系对隔离化合物的细胞毒性潜力.

主要方法:

种植Pseudohydropus,参见其他. 在尼古丁胺胺的存在下.
使用色谱技术分离和净化真菌代谢物.
使用光谱方法阐明新化合物的结构,包括修改后的莫舍尔方法来确定绝对配置.
对NCI-H187癌细胞的细胞毒性测定.

主要成果:

两种新的希尔苏类型的基烯分离出来,即基素A (1) 和B (2).
还确定了两种已知的hirsutanes,6,7-epoxy-4(15) -hirsutene-5-ol (3) 和6,7-epoxy-4(15) -hirsutene-1,5-diol (4),也被确定.
水素A (1) 和已知化合物3对NCI-H187癌细胞表现出弱细胞毒性,IC50值分别为161微米和144微米.
确定了水母系A的绝对配置.

结论:

种植Pseudohydropus cf. 这种植物的栽培. 帕拉富内布里与尼古丁胺产生了新型基.
亲蛋白A和B代表了 hirsutane 类的新增.
隔离的化合物具有较弱的细胞毒性活性,这表明在药物发现中可能需要进一步调查.

关键词:

在Porotheleaceaeae中使用.伪水类动物 Pseudohydropus 伪水 (Pseudohydropus) 参见其他. 帕拉富尼布里斯 (Parafunebris) 是一个细胞毒性细胞毒性希尔苏坦 (Hirsutane) 是一种修改后的莫舍尔方法.

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