孕产妇的食物来源信号在胎儿的上神经核中振荡,在它的生理时钟发育之前
Martin Sládek1, Pavel Houdek1, Tomáš Čajka2
1Laboratory of Biological Rhythms, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
PLoS biology
|September 26, 2025
概括
胎儿老鼠大脑中的生理时钟在发育过程中会接收来自母亲的节奏代谢信号. 这些母体信号会在胎儿内部时钟成熟之前影响胎儿的上神经核 (SCN).
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 代谢学 代谢学 代谢学
背景情况:
- 生理时钟在胎儿上神核 (SCN) 中的发展及其依赖于母亲的线索仍然不清楚.
- 了解这种早期发展对于理解昼夜节律的建立至关重要.
研究的目的:
- 为了研究从胎儿阶段到断奶后的老鼠SCN昼夜时钟的本体发生.
- 为了识别从母亲传播到胎儿的节奏代谢信号,影响SCN.
主要方法:
- 对关键时钟基因 (Per2,Nr1d1,Bmal1) 和与代谢相关的基因 (Dbp,E4bp4) 的每日表达特征分析.
- 在胚胎和产后大鼠中的SCN和血的时间解析代谢和脂质分析.
- 在不同发育阶段 (E19至P28) 评估基因表达和代谢物节奏.
主要成果:
- 在E19胎儿中没有正规的时钟基因节律,在出生后的第10天 (P10) 逐渐发展,Dbp节律性仍然成熟到P28.
- 代谢敏感基因E4bp4和母体代谢产物在胎儿SCN和血中显示节奏表达/水平,在出生后丢失 (P02) 并稍后重新出现.
- 胎儿SCN中的代谢和脂质连贯性急剧下降,节律性在出生后立即消失.
结论:
- 胎儿SCN在其内在的昼夜时钟发育之前接收了节奏性的母体代谢信息.
- 这些发现揭示了母胎沟通的新途径,影响了早期的昼夜系统发育.
- 在建立自主节律性之前,母亲的食物衍生代谢物在同步胎儿SCN方面发挥着关键作用.
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