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Updated: Jan 16, 2026

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics
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溶酶体LRRC8复合体对溶酶体pH,形态和全身葡萄糖代谢产生影响

Ashutosh Kumar1, Yonghui Zhao1, Litao Xie1

  • 1Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.

Science advances
|September 26, 2025
PubMed
概括

溶酶体上富含白的重复含有8 (LRRC8) 通道复合体调节细胞生长和新陈代谢. 破坏LRRC8A会损害 lysosomal 功能,导致胰岛素抵抗和改变小鼠的葡萄糖代谢.

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