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单立体多模式神经探针用于持续刺激和长期神经记录

Luxi Zhang^1,2,3, Shengming Wang¹, Jie Xia^1,2,3

¹College of Information Science and Electronic Engineering, Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou 310027, China.

Science advances

|September 26, 2025

概括

研究人员通过激光写入光纤上的电极开发了新的单立体神经探针. 这些探测器提供了增强的灵活性,生物相容性和高密度记录,用于先进的神经调制和监控.

科学领域:

神经工程是神经工程.
生物医疗设备生物医疗设备
神经接口的神经接口

背景情况:

长期的神经探针对于体内神经循环调制至关重要.
传统的探测器面临着机械刚性,电性能和生物相容性方面的挑战.

研究的目的:

开发一种新的单立体神经探头,集成光学刺激和电气记录.
为了克服传统"附加"探头设计的局限性.

主要方法:

在曲的光纤表面上直接激光写入电极阵列.
在单体探头的生物相容聚合物涂层中集成电极.
促进高密度通道的多层电极集成.

主要成果:

单体探头具有很高的机械曲耐力和稳定的阻抗.
证明了与减少炎症反应的改善生物相容性.
通过多层集成实现了高密度的电读取通道.

结论:

开发的单体神经探针代表了神经工程的重大进步.
这些探测器显示了未来神经监测和调制应用的前景.
直接激光写作方法为创建先进的神经接口提供了一种多功能方法.

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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