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使用微超声波与磁共振成像/超声波融合活检检测临床显著的前列腺癌:一个倾向权衡的比较研究

Rafael Castilho Borges^1,2, Rafael Rocha Tourinho-Barbosa³, Nuno Dias¹

¹Department of Urology, Institut Mutualiste Montsouris, Paris, France.

The Journal of urology

|September 26, 2025

概括

微超声导向活检 (MB) 显示,在MRI可见病变的男性中,临床显著的前列腺癌 (csPCa) 的检测率高于MRI/超声融合导向活检 (PFB). 然而,这种益处在所有患者子组和活检策略中并不一致.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
医疗成像医学成像
在瘤学瘤学.

背景情况:

前列腺癌的诊断依赖于准确的活检技术.
在诊断临床显著前列腺癌 (csPCa) 时,区分微超声导向活检 (MB) 和核磁共振/超声融合导向活检 (PFB) 是至关重要的.

研究的目的:

在MRI可见病变的男性中,比较MB和PFB之间的csPCa检测率.
评估这些活检技术在各种患者亚组中的性能,包括生检素的男性和前部病变患者.

主要方法:

在2019-2022年期间,对1119名接受MB (n=767) 或PFB (n=352) 的男性进行了回顾性分析.
应用治疗权重的逆概率来平衡基线特征.
权重后勤回归模型来比较csPCa检测和多变量模型来确定csPCa的预测因子.

主要成果:

调整后的分析显示,在组合采样中,与PFB相比,MB检测的csPCa更高 (45%对34%;OR,1.61;P<.01).
在单独针对性活检或在未经活检的男性和前部病变的男性中,在csPCa检测中没有发现显著差异.
在前列腺切除术时,格里森升级在PFB组中更频繁 (38%对17%;P = .01).

结论:

在调整后的分析中,MB在调整后的分析中显示出更高的csPCa检测,但这种益处并不普遍一致.
需要进行进一步的研究,以确定观察到的差异是由于方法上的优势还是背景特定因素.

关键词:

这就是为什么MRI是MRI.活组织活检检测检测检测检测检测前列腺癌是前列腺癌.超声波超声波是指超声波的使用.

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