甲状腺癌中的三级淋巴体结构
Katia Sakimi Nakadaira1, Kelly Cristina Saito1, Cesar Seigi Fuziwara1
1Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brasil.
Archives of endocrinology and metabolism
|September 26, 2025
概括
在41%的乳头甲状腺癌 (PTC) 样本中发现了三级淋巴状结构 (TLS),成熟的TLS中存在B细胞. 这些发现表明TLS可能在甲状腺癌中充当免疫生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 三级淋巴体结构 (TLS) 是在慢性炎症或感染期间在非淋巴体组织中发现的有组织的免疫细胞聚合物.
- 它们在瘤微环境 (TME) 中的存在越来越多地被认为是对调节抗瘤免疫力的作用.
- 了解甲状腺癌中TLS的形成和组成对于开发新型免疫治疗策略至关重要.
研究的目的:
- 调查乳头甲状腺癌 (PTC) 中的三级淋巴状结构 (TLS) 的存在,位置和成熟状态.
- 在 PTC TME 中的 TLS 的生殖中心内识别瘤透的 B 细胞.
- 为了将TLS存在与PTC的临床和分子特征相关联.
主要方法:
- 来自112名PTC患者的血素和欧染色组织学样本的形态评估.
- 免疫光染色用于检测成熟TLS中的B细胞.
- 通过cBioPortal对来自癌症基因组图谱 - 甲状腺癌 (TCGA-THCA) 数据集的499张扫描幻灯片进行分析.
主要成果:
- 在41%的PTC样本中发现了TLS,其中大多数位于周区域.
- 在15%的病例中,观察到含有B细胞和生殖中心的成熟TLS.
- 在8.4%的TCGA-THCA病例中发现了TLS,通常与BRAFV600E突变和升高的免疫标记物有关.
结论:
- 状甲状腺癌的瘤微环境中存在TLS.
- TLS的形态特征及其B细胞含量提供了作为免疫生物标记物的潜力.
- 在甲状腺癌中,TLS可能在调节瘤与免疫相互作用方面发挥重要作用.
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