Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

2.9K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.9K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

8.9K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.9K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

14.7K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
14.7K
The Thyroid Gland01:23

The Thyroid Gland

6.7K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.7K
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

4.4K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
4.4K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

MicroRNA expression signatures associated with metastatic progression in papillary thyroid carcinoma.

Archives of endocrinology and metabolism·2026
Same author

OCT4 and NANOG are involved in adrenocortical tumorigenesis.

Archives of endocrinology and metabolism·2026
Same author

MicroRNA signatures associated with radioiodine refractoriness and tumor dedifferentiation in metastatic papillary thyroid carcinoma.

Endocrine·2026
Same author

DNA Methylation-Based Risk Stratification and Classification of Pediatric Thyroid Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Dual Effect of <i>EZH2</i> Gene Editing with CRISPR/Cas9 in Lung Cancer.

Biology·2026
Same author

Afirma genomic sequencing classifier performance in young patients with cytologically indeterminate thyroid nodules.

The Journal of clinical endocrinology and metabolism·2026
Same journal

Response to the letter to the editor: Evaluation of three inflammation-associated blood indices for predicting malignancy in thyroid nodules.

Archives of endocrinology and metabolism·2026
Same journal

Comment on: Evaluation of three inflammation-associated blood indices for predicting malignancy in thyroid nodules.

Archives of endocrinology and metabolism·2026
Same journal

Goodbye, idiopathic short stature: why "healthy short stature" is a necessary advancement.

Archives of endocrinology and metabolism·2026
Same journal

Healthy short stature.

Archives of endocrinology and metabolism·2026
Same journal

Clinical characteristics, glycemic control & quality of life of patients using Android Artificial Pancreas System (AAPS) in Brazil.

Archives of endocrinology and metabolism·2026
Same journal

Pheochromocytoma and multicentric giant cell tumor of bone.

Archives of endocrinology and metabolism·2026
查看所有相关文章

相关实验视频

Updated: Jan 16, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

937

甲状腺癌中的三级淋巴体结构

Katia Sakimi Nakadaira1, Kelly Cristina Saito1, Cesar Seigi Fuziwara1

  • 1Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brasil.

Archives of endocrinology and metabolism
|September 26, 2025
PubMed
概括
此摘要是机器生成的。

在41%的乳头甲状腺癌 (PTC) 样本中发现了三级淋巴状结构 (TLS),成熟的TLS中存在B细胞. 这些发现表明TLS可能在甲状腺癌中充当免疫生物标志物.

关键词:
乳头甲状腺癌是一种乳头甲状腺癌.淋巴细胞新生代 新生代.形态分析分析 形态分析三级淋巴体结构成熟期的成熟瘤透的B细胞

更多相关视频

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.2K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.6K

相关实验视频

Last Updated: Jan 16, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

937
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.2K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.6K

科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 病理学 病理学 病理学

背景情况:

  • 三级淋巴体结构 (TLS) 是在慢性炎症或感染期间在非淋巴体组织中发现的有组织的免疫细胞聚合物.
  • 它们在瘤微环境 (TME) 中的存在越来越多地被认为是对调节抗瘤免疫力的作用.
  • 了解甲状腺癌中TLS的形成和组成对于开发新型免疫治疗策略至关重要.

研究的目的:

  • 调查乳头甲状腺癌 (PTC) 中的三级淋巴状结构 (TLS) 的存在,位置和成熟状态.
  • 在 PTC TME 中的 TLS 的生殖中心内识别瘤透的 B 细胞.
  • 为了将TLS存在与PTC的临床和分子特征相关联.

主要方法:

  • 来自112名PTC患者的血素和欧染色组织学样本的形态评估.
  • 免疫光染色用于检测成熟TLS中的B细胞.
  • 通过cBioPortal对来自癌症基因组图谱 - 甲状腺癌 (TCGA-THCA) 数据集的499张扫描幻灯片进行分析.

主要成果:

  • 在41%的PTC样本中发现了TLS,其中大多数位于周区域.
  • 在15%的病例中,观察到含有B细胞和生殖中心的成熟TLS.
  • 在8.4%的TCGA-THCA病例中发现了TLS,通常与BRAFV600E突变和升高的免疫标记物有关.

结论:

  • 状甲状腺癌的瘤微环境中存在TLS.
  • TLS的形态特征及其B细胞含量提供了作为免疫生物标记物的潜力.
  • 在甲状腺癌中,TLS可能在调节瘤与免疫相互作用方面发挥重要作用.