脂肪肝疾病中的阿波利波蛋白水平:系统性审查和元分析
Rania Abdulredha1, Giuseppe Guido Maria Scarlata2, Micha Gruber3
1Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania. rania_live@hotmail.de.
Journal of gastrointestinal and liver diseases : JGLD
|September 26, 2025
概括
脂蛋白变化与脂肪肝疾病 (FLD) 有关. 这次审查发现非酒精性脂肪肝 (NAFLD) 和代谢相关脂肪肝 (MAFLD) 患者的ApoA-I水平较低,ApoB/ApoB100水平较高,这表明生物标志物潜力.
科学领域:
- 生物化学 生化学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 脂肪肝病 (FLD) 是一种与代谢障碍相关的常见疾病.
- 脂蛋白 (Apo) 水平的变化可能为FLD诊断和管理提供了洞察力.
- 本研究系统地审查了各种FLD表型中的Apo水平变化.
研究的目的:
- 为了评估不同脂肪肝疾病表型中阿波利波蛋白水平的变化.
- 评估阿波利波蛋白作为FLD诊断生物标志物的潜力.
- 通过元分析来综合现有文献中的证据.
主要方法:
- 在PubMed,EMBASE和Scopus数据库中的系统文献搜索.
- 在研究选择中应用预定义的纳入和排除标准.
- 对55项研究 (432,328人) 的元分析,以确定Apo水平的平均差异 (MD).
主要成果:
- 与对照组相比,非酒精性脂肪性肝病 (NAFLD) 患者的ApoA-I (MD: -0.064) 值较低,ApoB (MD: 0.098) 和ApoB100 (MD: 0.042) 值较高.
- 非酒精性脂肪肝炎 (NASH) 患者表现出较低的ApoA-I (MD: -0.108) 和较高的ApoB (MD: 0.123).
- 与代谢相关的脂肪肝病 (MAFLD) 患者的ApoA-I较低 (MD: -0.068) 和ApoB较高 (MD: 0.099).
结论:
- 在NAFLD患者中,ApoA-I水平降低,而ApoB和ApoB100水平增加.
- 与简单肥胖症相比,NASH患者表现出较高的ApoB水平.
- 在MAFLD患者中,ApoB和ApoE水平升高,表明潜在的诊断价值.
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