传染性模型用于评估中环境影响的跨代传染
K Karami1, S Rousse1, F Pitel1
1GenPhySE, Université de Toulouse, INRAE, ENVT, 31326 Castanet-Tolosan, France.
Animal : an international journal of animal bioscience
|September 26, 2025
概括
环境影响,如中的基因斯坦暴露,可以通过表观遗传传下一代. 这项研究证明了对体重的跨代影响,表明了加速适应的潜力.
科学领域:
- 表观遗传学和跨代遗传学
- 动物育种与遗传学
- 环境毒理学环境毒理学
背景情况:
- 现象类型受到遗传和非遗传信息的影响,环境因素可能会在几代人之间传播.
- 表观遗传修饰,如DNA甲基化,可以调节环境暴露对后代的影响.
- 了解跨代影响对于预测环境变化的长期影响至关重要.
研究的目的:
- 通过使用实验性白模型来证明环境影响的垂直传播.
- 研究内分泌干扰物基因斯坦在调解跨代表观遗传中的作用.
- 量化归因于跨代环境影响的差异比例.
主要方法:
- 在长的三代人中采用了镜像交配设计,治疗线被食了补充基尼斯坦的饮食.
- 在多个年龄段进行了行为测试和体重测量,在屠宰时记录了身体和腹部脂肪重量.
- 一个混合效应的传染性模型,包括环境影响,用于估计差异组件和传输参数.
主要成果:
- 具有环境影响的可传播性模型显示,基因斯坦对体重特征的影响在几代人之间有显著的传播.
- 传播变异的比例从0.20到0.72不等,取决于特征和年龄.
- 据估计,Sire和Dam路径系数在0.42和0.52之间,与0.50没有显著差异,而环境传播的额外共变性对体重有意义.
结论:
- 基因斯坦诱导的环境对的体重的影响是跨代传递的,可能是通过表观遗传的介导.
- 这项研究为环境诱导的表型的垂直传播提供了证据.
- 研究结果表明,环境因素可以对多代人产生积极影响,在与遗传选择相结合时可能有助于适应.
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