在美国成年人中,暴露在制阻燃剂和胆结石风险之间存在关联
Xiuquan Shi1, Yangyang Li2, Lei Jin3
1The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui 230031, China; General Surgery Department, Yingshang County People's Hospital, Anhui 236200, China.
Ecotoxicology and environmental safety
|September 26, 2025
概括
制阻燃剂 (BFRs) 暴露与增加胆结石风险有关,特别是丁酸. 这表明环境污染物可能有助于胆结石的形成,这需要进一步调查BFR和健康结果.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 胆结石影响全球数百万人,并与代谢问题和污染物有关.
- 制阻燃剂 (BFR) 是持久性有机污染物,具有潜在的肝毒性.
- 之前关于BFR和胆结石的证据有限,需要进一步研究.
研究的目的:
- 为了研究血清BFR和胆结石风险之间的关联.
- 探索混合BFR暴露的非线性关系和累积效应.
- 检查潜在的调解机制,例如中性粒细胞与白蛋白的比率 (NAR).
主要方法:
- 从NHANES (2017-2020) 分析了2026名自我报告胆结石状况的参与者.
- 使用WQS回归和QGC等先进的统计模型测量了5个血清BFR.
- 利用受限立方线 (RCS) 模型和调解分析来评估复杂的关联.
主要成果:
- 四个BFR显示出与胆结石风险的积极关联.
- 混合BFR暴露与更高的胆结石患病率有关,而双酸是最重要的贡献者.
- 中性粒细胞与白蛋白的比率 (NAR) 介导了18.3%的双酸盐与胆结石之间的关联.
结论:
- 在研究的BFR中,双酸与胆结石患病率的关联最强.
- 研究结果表明,BFR暴露可能会增加胆结石风险,可能通过神经调节途径.
- 虽然并未确定因果关系,但这项研究强调了胆结石的潜在环境风险因素.
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