在水生无脊椎动物中化学生物积累的机制建模:以为基础的示范
Shaorong Chen1, Jie Xiong1, Zijian Li1
1School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong 518107, China.
Ecotoxicology and environmental safety
|September 26, 2025
概括
一个新的基于生理的动力学 (PBK) 模型准确地预测了中的化学生物积累. 这种模型有助于了解水生生态系统中关键无脊椎动物物种的污染途径和风险.
科学领域:
- 生态毒理学 生态毒理学
- 环境化学环境化学
- 水生无脊椎动物生理学
背景情况:
- 在水生无脊椎动物中化学生物积累对于理解污染物暴露和热量转移至关重要.
- 关键物种作为生态系统健康和污染物动态的指标.
研究的目的:
- 开发和验证一种基于生理学的动力学 (PBK) 模型,用于量化白腿 (Litopenaeus vannamei) 中有机污染物的生物积累因子 (BAF).
- 为了确定主要的积累点和主要的暴露途径,在的各种化学类别.
- 评估模型在一系列有机污染物的预测性能.
主要方法:
- 为Litopenaeus vannamei (血淋巴,消化道,,肌肉,,卵) 开发一个多组织PBK模型.
- 通过呼吸和饮食摄入的化学物质吸收的模拟.
- 模拟通过呼吸,分泌,生长,变和产卵来消除化学物质.
- 对101种有机污染物的模型预测与报告的BAF值进行比较.
主要成果:
- 该PBK模型与报告的BAFs有很好的一致性,其中50-80%的化学品偏离不到一个数量级.
- 对于疏水化合物 (Log Kow 4-6) 和制阻燃剂 (BFRs) 的模型性能最高.
- 对于Per-和多基基物质 (PFAS) 和某些农药,观察到显著的偏差,可能是由于未建模的新陈代谢或环境因素.
- 和蛋组织被确定为主要积累地点.
- 胆吸收占主导地位的疏水污染物,而饮食摄入是PFAS在消化系统中的积累的关键.
结论:
- 基于的PBK模型为机械理解类污染物动态提供了强大的工具.
- 该模型有助于评估化学风险,并了解水生环境中的暴露异质性.
- 需要进一步细化,以考虑代谢过程和沉积物-水相互作用,以提高某些化学类 (如PFAS) 的精度.
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