Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

[Effect of fluoride ion on corrosion of two dental titanium alloys].

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology·2010
Same author

The phylogeny analysis of MyoG gene in different pig breeds.

Interdisciplinary sciences, computational life sciences·2010
Same author

[Treatment of early avascular necrosis of femoral head by core decompression combined with autologous bone marrow mesenchymal stem cells transplantation].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery·2010
Same author

MicroRNAome of porcine pre- and postnatal development.

PloS one·2010
Same author

Hyperactive putamen in patients with paroxysmal kinesigenic choreoathetosis: a resting-state functional magnetic resonance imaging study.

Movement disorders : official journal of the Movement Disorder Society·2010
Same author

Danshensu has anti-tumor activity in B16F10 melanoma by inhibiting angiogenesis and tumor cell invasion.

European journal of pharmacology·2010

相关实验视频

Updated: Jan 16, 2026

Intra-lymph Node Injection of Biodegradable Polymer Particles
09:06

Intra-lymph Node Injection of Biodegradable Polymer Particles

Published on: January 2, 2014

15.1K

淋巴结向纳米药物用于瘤免疫疗法.

Xiaotong Li1, Ruiyin Cheng2, Deng Junyi2

  • 1Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510630, China.

Biomaterials
|September 26, 2025
PubMed
概括

针对淋巴结的纳米药物通过克服免疫抑制微环境来增强癌症免疫疗法. 这些策略改善T细胞激活和抗瘤免疫力,同时降低全身毒性.

关键词:
药物输送是药物输送的过程.淋巴结向的目标是淋巴结.纳米医学是一种纳米医学.瘤免疫疗法免疫疗法

更多相关视频

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.7K
Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
08:02

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

6.5K

相关实验视频

Last Updated: Jan 16, 2026

Intra-lymph Node Injection of Biodegradable Polymer Particles
09:06

Intra-lymph Node Injection of Biodegradable Polymer Particles

Published on: January 2, 2014

15.1K
Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.7K
Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
08:02

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

6.5K

科学领域:

  • 免疫学 免疫学 免疫学
  • 纳米医学是一种纳米医学.
  • 癌症治疗 癌症治疗

背景情况:

  • 淋巴结 (LN) 对于适应性免疫和癌症免疫疗法至关重要,但它们的免疫抑制微环境和全身药物输送限制了疗效.
  • 由于系统分布,常规疗法往往会导致非目标毒性.

研究的目的:

  • 审查免疫抑制性LN微环境和纳米药物交付中的挑战.
  • 提供LN向纳米医学设计和癌症免疫疗法的优化策略的概述.

主要方法:

  • 审查关于LN准策略的现有文献,包括被动和主动准.
  • 对淋巴吸收和LN积累的纳米粒子设计原则 (大小,电荷,可变形性,联体受体相互作用) 的分析.
  • 对持续的局部免疫调节的受控药物释放机制的讨论.

主要成果:

  • 针对LN的纳米药物可以增强LN内的抗原呈现和T细胞激活.
  • 策略包括优化纳米粒子特性用于淋巴吸收,并利用连接体-受体相互作用进行特定的向.
  • 控制释放系统使得持续的,局部的输送能够增强免疫调节效应.

结论:

  • 针对LN的纳米药物提供了一种有希望的方法来克服传统癌症免疫治疗的局限性.
  • 这些策略可以增强抗瘤免疫力,促进持久记忆反应,并提高临床可翻译性.
  • 为了有效地针对LN的免疫疗法,需要进一步的研究,整合机械洞察力和设计原则.