外周炎症和PSD-95水平与使用电子烟的尼古丁依赖个体的结构性大脑变化有关
Yehong Fang1, Yunkai Sun1, An Xie2
1Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China.
Drug and alcohol dependence
|September 26, 2025
概括
电子烟使用与年轻成年人的大脑结构变化和炎症有关. 这项研究发现了与电子烟使用相关的灰质体积和炎症标志物的差异.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 毒理学 毒理学 毒理学
背景情况:
- 在青少年和年轻人中,电子烟 (e-cig) 的使用量不断增加.
- 电子烟使用,全身炎症和大脑结构之间的联系不清楚.
研究的目的:
- 调查电子烟消费,全身炎症和大脑结构之间的关系.
- 在不同的物质使用组中比较炎症标志物和灰质体积 (GMV).
主要方法:
- 对215名参与者 (电子烟使用者,传统香烟使用者,双重使用者,健康对照者) 的横截面研究.
- 量化的外周血液标记物:高灵敏度C反应蛋白 (hs-CRP),S100β,神经元特异性酶,以及后突触密度蛋白-95 (PSD-95).
- 评估灰色物质体积 (GMV) 使用基于voxel的形态学.
主要成果:
- 显著的GMV差异在右上旋 (STG),赫斯克尔旋,丘脑和小脑.
- 与健康对照组相比,电子烟使用者显示S100β更高,PSD-95更低,右丘脑GMV减少.
- 在STG和thalamus中发现的炎症生物标志物PSD-95和GMV之间的相关性.
结论:
- 电子烟的消费与大脑结构的改变和外周炎症标志物有关.
- 表明在电子烟使用者中系统性炎症和大脑GMV变化之间存在潜在联系.
- 强调需要进一步研究使用电子烟对神经系统的影响.
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