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(N) - 甲甲氨基氨酸作为单氨基载体全抑制剂:扩大了N6组用于比托普稳定

Dilip K Tosh1, Matteo Pavan1, Laura B Kozell2

  • 1Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

European journal of medicinal chemistry
|September 26, 2025
PubMed
概括

研究人员修改了核糖类类似物,以研究它们对人类多巴胺转运体 (hDAT) 的影响. 较小的N6修改增强了hDAT结合,而较大的N6-(ω-phenyl-alkyl) 组通过进入新区域来抑制结合.

关键词:
多巴胺是一种多巴胺.单胺氨基酸是一种单胺氨基酸.核化物是一种核化物.结构活动关系结构.运输商 运输商 运输商

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