Tribulus terrestris补充剂对尿路类固醇特征的影响:一项短期试点研究
Lavinia Minotti1, Emilia Marchei2, Mariangela Biava3
1Department of Chemistry & Technology of Drugs, Sapienza University of Rome, Piazzale A Moro 5, Rome 00185, Italy; National Centre on Addiction and Doping, Istituto Superiore di Sanità, viale Regina Elena 299, Roma 00161, Italy.
Journal of pharmaceutical and biomedical analysis
|September 26, 2025
概括
短期 Tribulus terrestris (TT) 补充剂在男性或女性运动员中没有显著改变尿路类固醇配置. 这些发现质疑TT作为性能增强剂的有效性.
科学领域:
- 内分泌学 在内分泌学.
- 营养生物化学 营养生物化学
- 运动科学 运动科学 运动科学
背景情况:
- 类固醇代谢是关键的生理过程.
- 草药补充剂,如Tribulus terrestris (TT),因其所谓的人体效应而受欢迎.
- 了解TT对内源激素的影响至关重要.
研究的目的:
- 调查短期 Tribulus terrestris (TT) 补充对尿路类固醇特征的影响.
- 评估TT在休运动员中对类固醇代谢的潜在调节.
主要方法:
- 在两个月内从运动员补充TT的运动员收集尿液样本.
- 类固醇度和代谢比率使用气体染色学-并联质谱法 (GC-MS/MS) 来量化.
- 在补充剂前和后比较尿路类固醇配置文件.
主要成果:
- 在男性或女性运动员中,在TT前后补充剂之间没有观察到尿路类固醇特征的统计学上显著差异.
- 虽然注意到一些暂时的增加和减少,但个体间的变化率很高.
- TT补充剂似乎不会干扰内源性类固醇激素的循环.
结论:
- 短期 Tribulus terrestris (TT) 补充剂不会引起尿路类固醇激素配置的可测量变化.
- 这些发现质疑TT作为提高表现的药物的有效性.
- 需要对更大的队列和更长的持续时间进行进一步的机制研究.
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