99mTc-Sestamibi SPECT/CT和18F-Choline PET/CT的诊断性能,用于在患有原发性甲状腺功能过高的患者中定位功能过高的甲状腺腺体
Ante Mandic1, Ivana Kraljevic2,3, Tanja Skoric Polovina3
1Department of Endocrinology, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina.
这项研究比较了原发性副甲状腺症 (PHPT) 的成像技术. 18F-胆PET/CT在定位功能过高的甲状腺腺体方面显示出比99mTc-sestamibi SPECT/CT更高的准确性.
科学领域:
- 核医学是一种核医学.
- 放射学 放射学是一门学科.
- 内分泌学 在内分泌学.
背景情况:
- 原发性副甲状腺功能障碍症 (PHPT) 是一种由过度的副甲状腺激素分泌所表现的疾病.
- 准确地定位功能过高的副甲状腺对于成功的手术干预至关重要.
- 目前的成像方式包括99mTc-sestamibi SPECT/CT和18F-胆PET/CT.
研究的目的:
- 评估和比较99mTc-sestamibi SPECT/CT和18F-胆PET/CT的诊断性能.
- 评估这些成像技术在检测PHPT患者功能过高的副甲状腺腺的有用性.
- 在不确定的99mTc-sestamibi SPECT/CT发现之后,确定18F-胆PET/CT的有效性.
主要方法:
- 在2019年4月至2022年5月期间接受手术的83名PHPT患者的回顾性分析.
- 包括手术前99mTc-sestamibi SPECT/CT (81名患者) 或18F-胆PET/CT (33名患者) 的患者.
- 病理组织学报告作为准确性评估的参考标准.
主要成果:
- 总共有98个腺体在病理学上被确定.
- 损伤分析显示,99mTc-sestamibi SPECT/CT.的检测率为57%.
- 18F-胆PET/CT的检测率明显更高,达到90.3%.
结论:
- 在PHPT患者中,18F-胆PET/CT在定位功能过高的甲状腺腺体方面非常有效.
- 当99mTc-sestamibi SPECT/CT产生负面或不确定的结果时,这种技术特别有价值.
- 使用18F-胆PET/CT增强的局部精度可以改善PHPT的手术结果.
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