双A暴露与体外受精结果的关联:元分析和系统审查
Mengke Yuan1, Jie Chai2, Jingyan Song3
1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
Reproductive toxicology (Elmsford, N.Y.)
|September 26, 2025
概括
双甲 (BPA) 暴露对体外受精 (IVF) 和细胞内精子注射 (ICSI) 有负面影响,因为它降低了正常受精率和高质量的胚胎发育. 需要进一步的研究来证实这些关于生殖成功的发现.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- 双A (BPA) 是一种环境污染物,对辅助生殖技术的影响尚不清楚.
- 了解BPA对体外受精 (IVF) 和细胞内精子注射 (ICSI) 的影响对于生殖健康至关重要.
研究的目的:
- 系统地审查和对BPA暴露与IVF/ICSI结果之间的关联进行现有研究进行元分析.
- 量化BPA对关键生育指标的影响.
主要方法:
- 在主要数据库 (PubMed,科学网,EMBASE,科克兰图书馆) 进行了全面的文献搜索,截至2024年4月19日.
- 来自14项选定的研究的数据被用回归系数 (β) 和置信区间 (CI) 来进行元分析.
- 根据BPA暴露水平进行了子组分析.
主要成果:
- 暴露于BPA (尿液,血清,卵泡液,精液) 与正常受精率 (β: -0.05) 和高质量的胚胎数量 (β: -0.05) 有显著的负相关性.
- 较高的BPA暴露水平 (>1.55 ng/ml) 与正常受精率 (β: -0.19) 有较强的负相关性.
- 对于临床怀孕,胚胎细胞形成或植入率,没有发现显著的关联,可能是由于研究的局限性.
结论:
- 暴露于BPA可能会降低IVF/ICSI中的生殖成功,因为它会损害雌同体质量和早期胚胎发育.
- 这些发现表明,潜在的机制涉及内分泌干扰.
- 需要进一步的研究来证实这些结果,并阐明BPA生殖毒性的潜在机制.
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