针对DNA损伤:一种基于天然产品的策略,用于抑制癌症的进展
Jia-Xuan Wang1, Ming-Xiu Zhang2, Cheng-Hao Yu3
1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Innovative Drug Research Center, College of Life Sciences, Huaibei Normal University, Huaibei, 235000, China.
Journal of ethnopharmacology
|September 26, 2025
概括
传统医学的天然产品诱导DNA损伤,以对抗癌症的进展. 这些化合物通过多种机制向癌细胞来增强化疗效和减少副作用.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 由DNA损伤引起的基因组不稳定性是癌症进展的关键.
- 自然产品提供多目标,低毒性癌症治疗策略.
- 传统医学利用天然产品来获得治疗效益.
研究的目的:
- 审查传统医学的天然产品,通过DNA损伤抑制癌症.
- 澄清这些天然产品的多目标作用机制.
- 分析自然产品如何改善化疗,减少毒性,克服耐药性.
主要方法:
- 对英语和中文文章的系统文献综述 (2000年1月至2025年8月).
- 在PubMed,Elsevier,Springer,CNKI中使用关键词进行搜索:DNA损伤,天然产品,提取物.
- 查阅传统用途的古典文本;对获取的信息进行综合和批判分析.
主要成果:
- 已确定80多种活性天然产品,可诱导癌症治疗或疗法增强的DNA损伤.
- 对来源,效应和分子机制 (氧化应激,DNA修复抑制,细胞循环停止,细胞亡) 的系统概述.
- 分析包括类,黄类,类,糖类,多糖类和提取物.
结论:
- 通过DNA损伤途径,传统医学衍生的天然产品通过DNA损伤途径作为双重剂 (化学敏感化,细胞毒性) 起作用.
- 这一策略显示出克服瘤耐药性和推进精确瘤学的前景.
- 未来的研究应该专注于合成杀伤性,药物输送和临床适用性 (例如,PROTAC).
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