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在动脉样硬化和癌症中,含脂质的巨细胞

M C Martinez-Campanario¹, Marlies Cortés¹, Lu Han²

¹Group of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, IDIBAPS, Barcelona 08036, Spain; Biomedical Research Networking Center in Digestive and Hepatic Diseases (CIBEREHD), Carlos III Health Institute, Barcelona 08036, Spain.

Seminars in cancer biology

|September 26, 2025

概括

带有脂质的巨细胞 (LL-Macs) 在炎症,动脉样硬化和癌症中具有双重作用. 了解它们的脂质代谢和微环境是开发针对这些疾病的向治疗的关键.

科学领域:

免疫学免疫学免疫学
代谢性疾病代谢性疾病
在瘤学瘤学.

背景情况:

脂质新陈代谢在平衡和炎症期间显著影响巨细胞两极分化.
带脂质的巨细胞 (LL-Macs) 涉及动脉样硬化和癌症,表现出共同和不同的功能.
当地微环境极大地影响了巨细胞的脂质积累和在各种病理条件下的功能.

研究的目的:

探索LL-Macs在炎症,动脉样硬化和癌症中的双重作用.
阐明不同疾病背景下巨细胞脂质积累的分子机制.
评估基于动脉样硬化见解的癌症治疗脂质调节策略的潜力.

主要方法:

对LL-Macs在炎症,动脉样硬化和癌症方面的现有文献的审查.
对驱动巨细胞脂质积累的分子机制的分析.
对LL-Macs在动脉样硬化和癌症中的单细胞RNA测序 (scRNA-seq) 数据的检查.
评估脂质调节策略及其治疗潜力.

主要成果:

在动脉样硬化中,LL-Macs有助于斑块形成和炎症.
在癌症中,LL-Macs促进免疫抑制和瘤进展.
scRNA-seq揭示了LL-Macs跨疾病的共同和独特的基因特征,反映了微环境的影响.

结论:

在动脉样硬化和癌症中,LL-Macs扮演着复杂的,取决于背景的角色.
了解微环境线索对于破译LL-Mac功能至关重要.
准LL-Mac脂质代谢为癌症提供了潜在的治疗途径,基于动脉样硬化研究.

关键词:

动脉样硬化是一种动脉样硬化.癌症癌症癌症癌症免疫抑制是一种免疫抑制.脂质代谢脂质代谢是一种含有脂质的巨细胞充满了脂质.与瘤相关的巨细胞.

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