结构性和功能性大脑连接与青春期精神病理学维度的纵向关联
Lucy Vanes1, Divyangana Rakesh1, Tobias Banaschewski2
1Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|September 26, 2025
概括
青少年精神病理与大脑连接变化有关. 外向化症状会影响白质,而一般性困难会影响功能连接,这表明心理健康的关键发展时期.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 青春期是神经发育的一个关键阶段,精神健康问题越来越多.
- 在此期间,大脑连接性经历了显著的成熟.
研究的目的:
- 检查青少年心理病理和大脑连接之间的纵向联系.
- 研究白质微观结构和功能连接如何与随时间推移的心理健康症状有关.
主要方法:
- 使用了IMAGEN数据集,在三个时间点 (年龄为14,19,23) 超过1500名参与者.
- 评估白质 (WM) 微观结构使用扩散度量 (分数异构).
- 从静止状态的fMRI通过voxelwise度中心度 (DC) 测量功能连接.
主要成果:
- 外向化症状与减少白质分数异构 (FA) 相关联,特别是在皮质脊髓管中.
- 功能连接 (DC) 与前额和部区域的一般精神病理有关.
- 增加的总困难与较年轻个体的额头DC降低和时间DC改变有关.
结论:
- 大脑连接的发展和精神病理在青春期有动态的交织.
- 这些发现可能有助于识别敏感发育时期的风险和弹性神经标志物.
更多相关视频
相关概念视频
Biological Causes of Schizophrenia
501
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
501
Longitudinal Studies
479
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
479
Cognitive Development During Adolescence
503
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
503
Attention-Deficit/Hyperactivity Disorder
776
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
776
Theoretical Approaches to Psychological Disorder
778
The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
778
Longitudinal Research
13.1K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.1K


