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在中度阶段的病例中,区分初级开角,脱皮和初级闭角光眼,使用基于血液的炎症指数和结构指标

Atılım Armağan Demirtaş¹, Berna Yüce¹, Bediz Özen²

¹Department of Ophthalmology, University of Health Sciences Turkey, Izmir Faculty of Medicine, Izmir, Türkiye; Department of Ophthalmology, Izmir City Hospital, Izmir, Türkiye.

Photodiagnosis and photodynamic therapy

|September 26, 2025

概括

像中性粒细胞与淋巴细胞比率 (NLR) 和淋巴细胞与单细胞比率 (LMR) 这样的系统性炎症标志物显示出对分辨青光眼亚型的适度能力. 结构参数证实了青光眼的存在,但不是特定的亚型.

科学领域:

眼科医生眼科眼科
免疫学免疫学免疫学
血液学血液学血液学

背景情况:

玻璃眼包括各种亚型,包括初级开角玻璃眼 (POAG),脱皮玻璃眼 (XFG) 和初级闭角玻璃眼 (PACG).
区分这些青光眼类型,特别是在中度阶段,对于有效的管理至关重要.
系统性炎症标志物和眼部结构参数是潜在的诊断工具.

研究的目的:

评估中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和淋巴细胞与单细胞的比率 (LMR) 在区分POAG,XFG,PACG和健康对照时的区分实用性.
为了评估结构参数的性能,特别是杯对盘 (C/D) 比率和视网膜神经纤维层 (RNFL) 厚度,在区分这些条件时.

主要方法:

一项回顾性研究包括166名参与者 (40-70岁) 与POAG (n=55),XFG (n=51),PACG (n=30) 和对照 (n=30).
进行了眼科评估,光学连贯性断层扫描和标准自动周边测量.
系统性炎症标志物从全血细胞计数中计算出来,并进行接收器操作特征 (ROC) 分析.

主要成果:

两组之间没有发现年龄,性别或眼内压的显著差异.
玻璃杯与圆盘的比率在所有青光眼亚型与对照组相比显著更高 (p=0.001).
视网膜神经纤维层厚度在青光眼患者中较低,但在亚型之间没有显著差异 (p=0.057).
炎症指数没有显示显著的组间差异 (p>0.05),但ROC分析表明诊断价值适度.
淋巴细胞与单细胞比率 (LMR) 的AUC最高 (0.635),使POAG与对照区分开来.
中性粒细胞与淋巴细胞的比率 (NLR) 显示出中度的性能,使POAG与XFG (AUC=0.621) 和XFG与PACG (AUC=0.627) 不同.

结论:

系统性炎症指数 (NLR,LMR) 在区分青光眼亚型和对照组方面表现出适度的区分价值.
结构参数 (C/D比率,RNFL厚度) 证实了青光眼的存在,但在区分特定的青光眼亚型方面不可靠.

关键词:

杯子/盘子的比率是多少青光眼的亚型青光眼的亚型淋巴细胞/单细胞的比率中性粒细胞/淋巴细胞的比例.其他国家和地区.血小板/淋巴细胞的比率视网膜神经纤维层是一种神经纤维层.

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